Learning Inter-Modal Correspondence and Phenotypes From Multi-Modal Electronic Health Records

نویسندگان

چکیده

Non-negative tensor factorization has been shown a practical solution to automatically discover phenotypes from the electronic health records (EHR) with minimal human supervision. Such methods generally require an input describing inter-modal interactions be pre-established; however, correspondence between different modalities (e.g., medications and diagnoses) can often missing in practice. Although heuristic applied estimate them, they inevitably introduce errors, leads sub-optimal phenotype quality. This is particularly important for patients complex conditions critical care) as multiple diagnoses are simultaneously present records. To alleviate this problem EHR unobserved correspondence, we propose collective hidden interaction (cHITF) infer jointly discovery. We assume that observed matrix each modality marginalization of which reconstructed by maximizing likelihood matrices. Extensive experiments conducted on real-world MIMIC-III dataset demonstrate cHITF effectively infers clinically meaningful discovers more relevant diverse, achieves better predictive performance compared number state-of-the-art computational phenotyping models.

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ژورنال

عنوان ژورنال: IEEE Transactions on Knowledge and Data Engineering

سال: 2022

ISSN: ['1558-2191', '1041-4347', '2326-3865']

DOI: https://doi.org/10.1109/tkde.2020.3038211